A 43-year-old woman with bipolar disorder and advanced HIV infection was admitted to this hospital because of depressed mood, ...

Digital tobacco-cessation treatments hold great promise. But dedicated efforts will be required to promote access to and ...

Genetic deficiency of otoferlin, a protein critical to synaptic transmission by the sensory hair cells of the ear, causes congenital deafness. Medicines to treat the condition are lacking; ...

Magnesium is an important cofactor for numerous enzymes. All ATPase reactions require Mg 2+ –ATP, including those involved in RNA and DNA biologic functions. It opposes calcium actions and acts as a ...

Hairy-cell leukemia (HCL) is a rare, indolent neoplasm of mature B cells with hairlike surface projections that circulate in the blood and preferentially infiltrate the bone marrow and spleen. The ...

We and others identified retinoblastoma features that suggested that the tumors originate in long- and medium-wavelength cone precursors, and we discovered features of these cone precursors that ...

Malnutrition is common in older adults and has serious adverse consequences. The cause of malnutrition is usually multifactorial, owing to the interaction of physiological changes of aging, physical ...

In men, marked hypogonadism due to pituitary or testicular disease generally has readily recognizable clinical manifestations, such as decreases in libido and sexual activity, loss of secondary sex ...

This Journal feature begins with a case vignette highlighting a common clinical problem. Evidence supporting various strategies is then presented, followed by a review of formal guidelines, when they ...

This review covers clinical presentations and complications of measles, current recommendations, and the epidemiologic background of measles. It also addresses the current debates on immunization and ...

There is growing concern about the well-being of physicians and the consequences of poor well-being for physicians themselves, their patients, and the broader health care system. Diminished well-being ...

This Journal feature begins with a case vignette highlighting a common clinical problem. Evidence supporting various strategies is then presented, followed by a review of formal guidelines, when they ...