A 41-year-old man was evaluated for swelling in the ankles and syncope. CT of the chest showed bilateral mediastinal and ...

For decades after the identification of mpox in humans in the Democratic Republic of Congo (DRC) in 1970, the disease was largely confined to the rural areas of Central and West Africa and thus ...

The patients studied on the medical wards of the Boston City Hospital had been admitted primarily for treatment of severe liver disease or the complications of alcoholism. One patient was admitted ...

For decades, poor treatment options and low-quality evidence plagued care for patients with rifampin-resistant tuberculosis. The advent of new drugs to treat tuberculosis and enhanced funding now ...

This Journal feature begins with a case vignette highlighting a common clinical problem. Evidence supporting various strategies is then presented, followed by a review of formal guidelines, when ...

Two patients with congenital generalized lipodystrophy type 1 due to a variant in AGPAT2 (c.589-2A→G) who had been receiving insulin and metreleptin were switched to tirzepatide and were ...

This feature about a child unvaccinated against measles, mumps, and rubella offers a case vignette accompanied by two essays, one supporting accepting the child as a patient without mandating the ...

New catheter materials for peripherally inserted central catheters (PICCs) may reduce the risk of device failure due to infectious, thrombotic, and catheter occlusion events. However, data from ...

The Race and Medicine collection reflects NEJM’s commitment to understanding and combating racism as a public health and human rights crisis. Our commitment to antiracism includes efforts to ...

ABOUT twenty years ago, a new procedure for lengthening the Achilles tendon was first employed. It is known as triple hemisection. Dr. Michael Hoke, who is believed to have been the first to use ...