Lipid-based Nanoparticles (LBNPs) have emerged as a transformative approach in cancer treatment, offering innovative drug delivery solutions that enhance therapeutic efficacy while minimizing adverse ...

Guanidine alkaloids widely exist in terrestrial microorganisms, peptides, and marine invertebrates, and have a multitude of biological activities. Consequently, these molecules have attracted ...

Proteolysis targeting chimera (PROTAC) technology has emerged as a powerful tool in drug discovery that enables targeted protein degradation through a unique bifunctional approach. This review ...

The concept of food and medicine homology (FMH) is deeply embedded in traditional Chinese medicine and carries historical importance. The recent rigorous definition of FMH pertains to substances that ...

Novel delivery strategies, nanoparticles, liposomes, solid lipid carriers, and PEGylated formulations have been developed to overcome poor oral absorption, enhance CNS penetration, and protect the ...

1 Figure in parentheses is the finishing days. 2 Experiment 1: 15-point scale, 1 = leanest; Experiment 2: 5-point scale, 1 = leanest. 3 Hunter L, a, b colour space: L = lightness, a = redness, b = ...

We report evidence of a likely low-altitude cosmic airburst near Perkins, Louisiana, associated with semi-consolidated deposits containing abundant shocked quartz grains, a classical impact indicator, ...

Abbreviations and acronyms: AF, Atrial fibrillation; CA, Catheter ablation; LA, Left atrium; LV, Left ventricle; HR, Hazard ratio; NYHA, New York Heart Association ...

Objective: This study was aimed at exploring immune-related genes and their expression changes in myocardial infarction (MI) through comprehensive bioinformatics methods and validating these genes as ...

Fatty acid (FA) reprogramming has a significant role in liver cancer. However, the contribution of FA metabolism reprogramming to the heterogeneity of hepatocellular carcinoma (HCC) has not been ...

Mitochondrial quality control (MQC) mechanisms – including biogenesis, dynamics, mitophagy, proteostasis, the unfolded protein response, and mitochondrial-derived vesicles – play critical roles in the ...

We report diverse shock-metamorphosed and melted grains from the 1908 airburst site in Russia, one of history’s most significant and enigmatic cosmic events. Analysis of samples from a rimmed ...