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前期研究表明，随着帕金森病不断进展，身体分泌的“皮脂”释放的挥发性有机化合物（VOCs）也有所不同，进而导致体味发生变化。这一结论为研究人员提供了思路，他们意识到，相比暴露于外界的皮肤皮脂，耳垢中的挥发性有机化合物受到外界的影响更小、更稳定，检测的准确率也就更高。