An expert discusses how the PEACE III combination of radium-223 and enzalutamide represents an effective treatment option for the limited population of patients who reach first-line metastatic ...

A new study by University of Michigan Rogel Cancer Center researchers identifies a cellular signature that explains why about ...

Prostate cancer is one of the most common malignancies in men globally. Hormonal therapies targeting the androgen–androgen receptor axis have significantly delayed disease progression. However, drug ...

SPOP mutations in veterans with metastatic castration-resistant prostate cancer (mCRPC) and the association with race and response to an androgen receptor pathway inhibitor (ARPI).

Overall survival outcomes with sipuleucel-T (Sip-T) among Black men with metastatic castrate-resistant prostate cancer (mCRPC) also treated with androgen receptor pathway inhibitors (ARPI).

Androgen receptor pathway inhibitors (ARPIs) as monotherapy are studied increasingly across prostate cancer disease states. We aimed to evaluate the safety, oncologic efficacy, and quality of life ...

Recently, combined therapy with androgen deprivation therapy and androgen receptor pathway inhibitors has been recommended for metastatic hormone-sensitive prostate cancer patients.

Purpose:. The current front-line therapies for men with metastatic prostate cancer are novel androgen receptor pathway inhibitors (ARPIs), such as abiraterone acetate or enzalutamide, which target the ...

ASCO GU 2025, metastatic castration resistant prostate cancer (mCRPC), VISION trial, 177Lu-PSMA-617, 177Lu-PSMA-617 with and Without Concurrent Use of Androgen Receptor Pathway Inhibitors in Patients ...

AR has emerged as a fourth receptor in BC and as a promising target, especially for those patients who do not respond to current hormone receptor-targeted therapies. In this study, we investigated the ...

Conversely, pre-receptor control of “androgen” metabolism, which is dictated by tissue localization and abundance of steroidogenic enzymes and metabolism, ultimately determines activity of the ...