Excessive cell death has been associated with chronic inflammation as seen in patients with Crohn's disease and ulcerative colitis. While until recently apoptosis was discussed as being essential for ...

Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) selectively induces apoptosis of tumor cells but not most normal cells. Its roles in normal nontransformed tissues are not clear.

which revealed a unique phenomenon whereby cells at a distance from the injury upregulate caspase activity in a process called Necrosis-induced Apoptosis (NiA) that is vital for regeneration. Here we ...

helped us understand the mechanisms by which these genes control apoptosis. The structure of CD95 suggested that it belonged to the tumour necrosis factor (TNF) receptor family and that there ...

In tumour cells with defects in apoptosis, autophagy allows prolonged ... autophagy provides a protective function to limit tumour necrosis and inflammation, and to mitigate genome damage in ...

Department of Dermatology of the Affiliated Hospital of China Medical University. Department of Dermatology of the Affiliated Hospital of Guiyang Medical University. Apoptosis is involved in aging and ...

Hepatocellular DILI is characterized by inflammation, necrosis, and apoptosis, while cholestatic DILI involves bile plug formation and bile duct paucity. Ursodeoxycholic acid (UDCA), a widely used ...

Discover how circulating cell-free DNA (cfDNA) is transforming the diagnosis and monitoring of metabolic diseases like ...

The experiment also revealed a rapid transition from apoptosis (natural programmed cell death) to late apoptosis/necrosis (cell death due to external toxins) between 3 and 24 h post-treatment. Indeed, ...

Fat necrosis refers to dead or damaged breast tissue that often manifests as a noncancerous lump under the skin. In most cases, these lumps go away on their own and don’t return. Fat necrosis of ...

Combining an existing small-molecule protein therapy called tumor necrosis factor related apoptosis-inducing ligand (TRAIL) with focused ultrasound (FUS) can significantly reduce tumor size and ...