Preclinical models of Parkinson's disease (PD) have been developed using intracerebroventricular (i.c.v.) injection of 6-hydroxydopamine (6-OHDA) to induce neurodegeneration and motor dysfunction.

These observations suggest that the deregulation of the PML pathway by PML-RARα is crucial ... ceramide and IFN apoptotic pathways normally deputed to induce apoptosis upon DNA damage or ...

This manuscript reports fundamental discoveries on how necrotic cells contribute to organ regeneration through apoptotic signalling to produce cells with non-lethal apoptotic caspase activity that ...

Mushrooms found in the forests of Bankura and Birbhum in West Bengal could become a game-changer in cancer treatment.

Ubiquitin-specific proteases play a critical role in regulating cell death pathways in breast cancer, affecting tumor ...

This review highlights the critical role of ubiquitin-specific proteases (USPs) in regulating programmed cell death (PCD) in breast cancer (BC). As the most prevalent malignant tumor among women, BC ...

Autophagy is a cellular degradation pathway for the clearance of damaged or superfluous proteins and organelles. The recycling of these intracellular constituents also serves as an alternative ...

Meanwhile, a New Drug Application (NDA) for another one of Ascentage Pharma’s key drug candidates, the novel Bcl-2 selective inhibitor lisaftoclax (APG-2575), has already been accepted and granted the ...

Emerging non-apoptotic PCD pathways such as ferroptosis ... Pyroptosis, an inflammatory cell death pathway, is also examined, with a focus on USP48 and gasdermin E (GSDME), which contribute ...

[5] Pecina-Slaus (2010) Wnt signal transduction pathway and apoptosis: a review. Cancer Cell Int ... [47] Rochette and Brash (2008) Progressive apoptosis resistance prior to senescence and control by ...

Discover how circulating cell-free DNA (cfDNA) is transforming the diagnosis and monitoring of metabolic diseases like ...