LC3-II is used as a marker of autophagy because its lipidation and specific recruitment to autophagosomes provides a shift from diffuse to punctate staining of the protein and increases its ...

Autophagy-related protein 8 (ATG8) family proteins, including LC3 and GABARAP subfamilies, are pivotal in canonical autophagy, driving autophagosome formation, cargo selection, and lysosomal fusion.

The defect in autophagy by the depletion of axonal mitochondria is one of the main claims in the paper. The authors should work more on describing their results of LC3-II/LC3-I ratio, as there are ...

In summary, STING can induce non-canonical formation of autophagosomes via WIPI2 using the ERGIC as a source for autophagosome lipidation and promotes autophagy-independent LC3 lipidation. However, ...

In 2000, it was suggested to me that “Autophagy will be the wave of the future; it will become the new apoptosis.” Few people would have agreed at the time, but this statement turned out to be ...

The roles of key proteins such as the microtubule-associated protein 1 light chain 3 (LC3), beclin 1, and p62 in autophagy initiation and substrate recognition were also explored. Further ...

This study presents a valuable finding on the alterations in the autophagic-lysosomal pathway in a Huntington's disease model. The evidence supporting the claims of the authors is solid. However, the ...

While autophagy is relevant to many biological processes and often serves as a gatekeeper of homeostasis, when something goes wrong it can either lead to disease or be activated to fight against it.

Recycling takes place in our cells at all times: in a process called autophagy, cell components that are no longer needed are enclosed by membranes and broken down into their basic building blocks.

Department of Chemical Sciences, Tata Institute of Fundamental Research, Mumbai 400005, India ...

复旦大学附属中山医院等多单位的研究人员 Linnan Li、Hao Cheng 等人在《Cell Death Discovery》期刊上发表了题为 “METTL3 regulates autophagy of hypoxia - induced cardiomyocytes by targeting ATG7” 的论文。该研究揭示了 METTL3 ...

Henan Key Laboratory of Environmental and Animal Product Safety, College of Animal Science and Technology, Henan University of Science and Technology, Luoyang 471000, Henan,China ...