The ability to regulate blood sugar is essential to our health. When beta cells first recognize higher glucose levels, they depolarize to trigger an increase in intracellular calcium and the rapid ...
Chronic exposure to hyperglycemia can lead to cellular dysfunction that may become irreversible over time, a process that is termed glucose toxicity. Our perspective about glucose toxicity as it ...
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Researchers at IISc Bengaluru discover potential drug-free treatment for diabetes by enhancing beta-cell function with small molecules.
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Increased levels of glucose in the circulation lead to increased glucose uptake into pancreatic beta cells through GLUT2, a glucose transporter. Increased intracellular glucose then leads to ...
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For example, beta cells secrete insulin in response to increased blood glucose levels, and this stimulates cells to take up glucose, an essential step in energy homeostasis. In contrast ...
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