Sunburns and aging skin are obvious effects of exposure to harmful UV rays, tobacco smoke and other carcinogens. But the effects aren't just skin deep. Inside the body, DNA is literally being torn ...

The Summit supercomputer revealed how damaged strands of DNA are surgically repaired by a molecular pathway called nucleotide ...

Researchers at Georgia State University used the Summit supercomputer to study an elaborate molecular pathway called ...

A double-strand DNA break (DSB ... microscopy to show how the helicase domain of DNA polymerase θ aligns broken DNA strands by matching short sequences, a process linked to cancer.

They are formed in a woman's body before birth and have to be on standby for decades to possibly be fertilized one day. But ...

A new structural blueprint paves the way for improved targeting of cancer cells, particularly those with BRCA1 and BRCA2 ...

Once a matching sequence is found, Pol-theta holds the broken DNA strands together so that they can be stitched together ... In addition to Lander and Zerio, authors of the study, "Human polymerase θ ...

DNA repair proteins act like the body's editors, constantly finding and reversing damage to our genetic code. Researchers have long struggled to understand how cancer cells hijack one of these ...

The Pol-theta enzyme (blue) joins two parts of a broken DNA strand (yellow). This process is mutagenic and can give rise to cancer.

Scientists at Scripps Research have now captured the first detailed images of the DNA repair protein, Pol-theta, in action, ...

DNA repair proteins act like the body's editors, constantly finding and reversing damage to our genetic code. Researchers have long ...