Sunburns and aging skin are obvious effects of exposure to harmful UV rays, tobacco smoke and other carcinogens. But the ...

A new structural blueprint paves the way for improved targeting of cancer cells, particularly those with BRCA1 and BRCA2 ...

Our DNA is constantly under threat — from cell division errors to external factors like sunlight and smoking. Fortunately, ...

The Pol-theta enzyme (blue) joins two parts of a broken DNA strand (yellow). This process is mutagenic and can give rise to cancer.

They are formed in a woman's body before birth and have to be on standby for decades to possibly be fertilized one day. But ...

The NTase domain binds to the broken DNA strands at and flanking the nick, the OB domain contacts the continuous template strand surrounding the nick, and the HhH domain binds both strands across the ...

A double-strand DNA break (DSB ... microscopy to show how the helicase domain of DNA polymerase θ aligns broken DNA strands by matching short sequences, a process linked to cancer.

Scientists at Scripps Research have now captured the first detailed images of the DNA repair protein, Pol-theta, in action, ...

Once a matching sequence is found, Pol-theta holds the broken DNA strands together so that they ... "Human polymerase θ ...

Researchers at Georgia State University used the Summit supercomputer to study an elaborate molecular pathway called ...