Your DNA is continually damaged by sources both inside and outside your body. One especially severe form of damage called a ...

DNA damage has been associated with aging and disease. Double-strand breaks are one of the worst forms of damage. New research shines a light on the repair process.

BERKELEY, CA — Ionizing radiation, toxic chemicals, and other agents continually damage the body's DNA, threatening life and health: unrepaired DNA can lead to mutations, which in turn can lead ...

Repair of broken chromosomes and triggering of the DNA damage response Broken chromosomes must be repaired if a cell is to survive; consequently cells have evolved a variety of mechanisms to repair ...

Scientists at St. Jude Children's Research Hospital have identified the structure of double-strand DNA break repair by PARP enzymes. The findings show that PARP2 can bridge the gap, bringing two ...

If DNA Is Broken, This ... “We saw that XPG makes a beeline for discontinuous DNA—places where the hydrogen bonds between bases on each strand of the helix have been disrupted—and ...

DNA damage plays a role in the pathogenesis of heart failure. On a bright sunny day, it’s second nature to protect our skin from ultraviolet damage with sunscreen. By applying this protective spray, ...

The findings, presented by Dr. Enrique Gonzalez-Duran and Prof. Dr. Ralph Bock from the Max Planck Institute of Molecular Plant Physiology in Nature Plants ("Suppression of plastid-to-nucleus gene ...

Researchers from Osaka University have found that protein phosphatase 1 binds to RIF1 at double-strand DNA breaks to promote repair by the non-homologous end joining pathway instead of the ...