BioIVT, a global research partner and biospecimen solutions provider for drug and diagnostic development, today announced the opening of its Hepatocyte Grants Program and that it is actively reviewing ...

Drug-drug interaction (“DDI”) clinical studies help identify the potential for side effects, or in some cases, reduced therapeutic efficacy, that may be caused by interactions between different drugs.

Merck will share new scientific findings from its HIV clinical development programs, including Phase 2 data on the safety and pharmacokinetics of MK-8527, an investigational, novel nucleoside reverse ...

Liquidia Corporation (NASDAQ: LQDA), a biopharmaceutical company developing innovative therapies for patients with rare cardiopulmonary disease, today announced the receipt of an additional $50.0 ...

Mastering DDI Risk Assessment: Predict CYP Enzyme-Mediated DDIs with Confidence 关于视频字幕 本视频仅有英文字幕，无中文字幕 01 课程概述 本次课程由Simulations Plus的法规事务部副总裁的张新元和PBPK首席科技官Viera ...

Background Amlodipine inhibits cytochrome P450 (CYP) enzyme and has the potential to reduce clopidogrel bioactivation in vivo. Reports in previous retrospective studies described greater platelet ...

However, Revatio is used for pulmonary arterial hypertension (PAH), whereas Viagra is used for erectile dysfunction (ED). Because of their different uses, the brand-name medications differ ...

One promising approach to cancer gene therapy is to introduce genes that encode anticancer prodrug metabolizing enzymes like Cytochrome P450 (CYP) enzymes, which aid in the successful elimination of ...

This script embodies cutting-edge algorithms to augment traditional molecular docking, FITTED, processes with machine learning for the prediction of Cytochrome P450 (CYP) enzyme inhibition. Sections: ...

In April of 2021, Dr. Brian Ogilvie, Vice President of Scientific Consulting at BioIVT, provided an overview of these pathways including a discussion of regulatory interest, case examples, in vitro ...

The CYP enzyme reacts with foreign compounds that enter an animal's body (for example, chemicals or pollutants in food, or medicines). CYP can convert them into water-soluble compounds and promote ...