Aim: The present study aimed to investigate the human genetic diversity of the CYP450 superfamily in order to identify functional interethnic differences and analyze the role of CYP450 enzymes in ...

Cytochrome P450 enzymes (CYPs) are a large family of enzymes that play a crucial role in the metabolism of various substances, including drugs and xenobiotics (foreign compounds). In cancer ...

In CB91, each atropisomer is metabolized at a similar rate. Figure 3: Human CYP enzymes’ metabolite formation activity against chiral PCB atropisomers Figure 4: Docking model of human CYP enzyme ...

Cytochrome P450 enzymes are a crucial family of enzymes involved in the metabolism of a wide range of substances, including drugs and endogenous compounds. They play a significant role in drug ...

Microbial factories provide a sustainable alternative to tree sap for producing elusive plant molecules, offering new ...

These compounds are broken down by an enzyme in the intestines called cytochrome P450 3A4 (CYP3A4). The resulting products will then bind to the enzyme, which prevents it from breaking down the ...

While grapefruit does not directly alter your medication, it does interact with an enzyme in your intestinal tract known as CYP3A4 [1]. This enzyme, when working normally, regulates how much of ...

The application of pharmacogenetics in identifying single nucleotide polymorphisms (SNPs) in DNA sequences that cause clinically significant alterations in drug-metabolizing enzyme activities is ...