本研究揭示了肝细胞caspase-8通过非凋亡机制驱动代谢功能障碍相关脂肪性肝炎（MASH）纤维化的新通路。研究人员发现caspase-8-YY1轴诱导meteorin分泌，经c-Kit-STAT3途径激活肝星状细胞（HSC），促进胶原沉积。该研究为MASH纤维化提供了新的治疗靶点，解释了靶向凋亡 ...

Most cases of autoimmune lymphoproliferative syndrome (ALPS) are associated with heterozygous mutations in the genes encoding CD95 (Fas receptor), CD95 ligand and the apoptotic enzyme caspase-10.

The c-Jun N-terminal kinase (JNK) signaling pathway mediates adaptation to stress signals and has been associated with cell death, cell proliferation, and malignant transformation in the liver.

Scientists use cell death, whether by apoptosis or necrosis, to evaluate the toxicity or effectiveness of substances of interest, including potential therapeutic agents. For example, researchers will ...