Caspase-8/caspase-3/GSDME-mediated pyroptosis siRNA敲低GSDME使焦亡细胞减少70%（P<0.001），LDH释放下降50%。 caspase-3抑制剂Z-DEVD-FMK和泛caspase抑制剂Z-VAD-FMK均能阻断GSDME剪切。

本研究聚焦支气管肺发育不良（BPD）中肺泡上皮细胞程序性死亡（PCD）的调控机制，揭示了Caspase-8通过激活NLRP3炎症小体促进细胞焦亡（pyroptosis）与凋亡（apoptosis）的交叉对话，加剧肺损伤的关键作用。研究人员通过构建高氧暴露的体内外BPD模型，采用Caspase-8抑制剂（Casp8i）干预，发现其可显著抑制 ...

细胞凋亡不仅是生物体发育、组织稳态维持及免疫防御的关键机制，更是疾病发生、发展及治疗策略制定的重要靶点。施教授认为在细胞凋亡领域有两大问题还未彻底解决：首先，尽管细胞凋亡的许多机理问题已经通过生物物理和结构生物学手段解释了很多，但 ...

S-腺苷甲硫氨酸（SAM）作为甲硫氨酸代谢的关键产物，具有抗炎特性，其水平下降与肝病、神经退行性疾病等多种疾病相关。然而，SAM如何独立于mTORC1通路调控细胞死亡仍不清楚。另一方面，RIPK1作为细胞死亡与炎症的核心介质，其激活机制（尤其与营养信 ...

Watch FOX 8 News on the new FOX 8 CLE+ TV streaming app! How to download by: Darcie Loreno Posted: Jul 2, 2025 / 06:09 AM EDT Updated: Jul 2, 2025 / 11:55 AM EDT CLEVELAND (WJW) — FOX 8 is growing.

The nervous system undergoes functional modification independent of cell turnover. Caspase participates in reversible neuronal modulation via non-lethal activation. However, the mechanism that enables ...

If you're excited about the upcoming Snapdragon 8 Elite phones, you're in for a treat. There are some seriously powerful devices on the way. The iQOO 13 and OnePlus 13 are just around the corner ...

Don't worry, everything is more '100 years of Rick and Morty' than ever now. Below, we've got the confirmed Rick and Morty season 8, episode 7 release date on Adult Swim, plus all the streaming ...

Ocean's 8 isn't quite as smooth as its predecessors, but still has enough cast chemistry and flair to lift the price of a ticket from filmgoers up for an undemanding caper. Read Critics Reviews ...

【导读】结直肠癌（CRC）的治疗仍面临挑战，原因是存在化疗耐药性。7月1日，苏州大学研究团队在期刊《Cell Death Discovery》上发表了研究论文，题为“N6-methyladenosine modification of MEF2A ...