Lysosomes are membrane-bound organelles whose acidic lumen (pH 4.5–5.0) is required for degradation. This luminal acidity is ...

All life on Earth shares a common ancestor that lived roughly four billion years ago. This so-called "last universal common ...

Researchers describe a rare type of gene family, known as “universal paralogs”, that provides insight into evolutionary history predating the last universal common ancestor of all life. Detailed ...

Membrane proteins are vital for cellular signaling, transport, and communication, making them attractive drug targets despite their challenging properties. Advances in mass spectrometry have enabled ...

Knowing which lysosomal proteins are enriched in which brain cell types will help better understand contribution to neurological disorders.

Ancient duplicated genes are giving scientists their first real clues about what life was like before all life on Earth shared a common ancestor.

Researchers have developed technologies that allow damaged proteins to be shredded or healthy ones installed. This may ...

Three Ohio State researchers earned the NAI fellow, the highest distinction awarded to inventors for their work in various fields. Dehua Pei, a professor in chemistry and biochemistry, was elected to ...

All life on Earth shares a common ancestor that lived roughly four billion years ago. This so-called "last universal common ancestor" represents the ...

Cells organize their molecules into distinct functional areas. While textbooks usually refer to membrane-bound organelles ...

BACKGROUND: The disruption of the blood–brain barrier (BBB) is a central pathogenic event in many central nervous system disorders. However, the mechanisms regulating BBB function remain incompletely ...