Researchers at Linköping University in Sweden made an unexpected discovery while investigating genetically unique women.

In cats, the fur pigmentation gene is X-linked, and depending on which copy of the X chromosome each cell chooses to leave active, either an orange or black coat color results. X inactivation only ...

基因表达调控在不同性别之间展现出令人惊叹的分子巧思，仿佛一场精心编排的生命双重奏。X染色体失活（X chromosome inactivation，XCI）是雌性哺乳动物体细胞中通过异染色质化随机失活一条X染色体的过程，是实现基因剂量平衡的重要机制。过往的大量研究证实 ...

In each female cell, one X chromosome must be inactivated—crumpled up in such a way that the genetic code it contains cannot be read out. RNA plays an important role in this inactivation process.

The silencing of the one X chromosome in XX cells is mediated by XIST, a long noncoding RNA that is randomly transcribed from only one X early in development. It coats the DNA and shuts down gene ...

About one-quarter of the hundreds of genes on the inactivated X chromosome in XX cells manage to escape that silencing, at least some of the time. When X-linked genes evade silencing on the “inactive” ...

UCSF researchers found that brain cells age more quickly when they rely solely on the X chromosome inherited from a female's ...

A UCSF study reveals that maternal X chromosome expression may accelerate brain aging and cognitive decline. Female mice with ...

The X contains more genes related to brain function than does any other chromosome. “The X chromosome may be a treasure trove ...