Orange cats have always stood out in the living room, but new research shows they also stand apart in the mammal family tree.

In this issue, Hoelzl and colleagues catalog genes that escape inactivation in major organs throughout the mouse lifespan and reveal that aging promotes reactivation of the X chromosome at distal ...

Autoimmune diseases, where the body attacks itself, are surging, disproportionately affecting women. Research points to the X chromosome, genetics, and environmental factors as key contributors. While ...

Background Hereditary haemorrhagic telangiectasia (HHT) and juvenile polyposis syndrome (JPS) can be caused by SMAD4 pathogenic variants. SMAD4 is a common transcription factor of the BMP/TGFβ ...