In cats, the fur pigmentation gene is X-linked, and depending on which copy of the X chromosome each cell chooses to leave active, either an orange or black coat color results. X inactivation only ...

In each female cell, one X chromosome must be inactivated—crumpled up in such a way that the genetic code it contains cannot be read out. RNA plays an important role in this inactivation process.

However, the process of X-inactivation is not complete. As many as 20% of the genes on the inactivated X chromosome may still be used, meaning that cells in women have more of these genes than ...

(A) The de novo inactivation model requires many rounds of inactivation and reactivation: the paternal germline initiates meiotic sex-chromosome inactivation, but the X chromosome is completely ...

The silencing of the one X chromosome in XX cells is mediated by XIST, a long noncoding RNA that is randomly transcribed from only one X early in development. It coats the DNA and shuts down gene ...

Women are more prone to autoimmune diseases due to genetic, hormonal, and environmental factors. We got in touch with an expert who explains how the X chromosome, estrogen levels, and lifestyle ...

and the red and green fluorescent lines were bred to generate heterozygous females containing one of each X chromosome. The team analyzed the green and red fluorescence in each cell in which Cre was ...