A closeup look at colibactin’s structure reveals chemical motifs that guide its mutation-wreaking “warheads” to specific stretches of DNA.

Colibactin is a powerful toxin produced by Escherichia coli and other bacteria living in the human gut. This highly unstable ...

Chemical insight into biological function is the holy grail of structural biology. Small molecules are central players as building blocks, effectors and probes of macromolecular structure and function ...

James Watson, a Nobel laureate and former director of the Cold Spring Harbor Laboratory (CSHL), died Nov. 6 at the age of 97. Watson shared the 1962 Nobel Prize in Physiology or Medicine with Francis ...

Professor Dongsheng Liu of Tsinghua University, Professor Ziyang Hao of Capital Medical University, and Researcher Yuanchen ...

RNA, widely known from the COVID-19 vaccine, is not actually a "therapeutic agent," but a technology that delivers the ...

A polymer is a substance made of many repeating units linked together, like beads on a string. Plastics are polymers, and so ...

The microbe Pyrodictium abyssi is an archaeon—a member of what's known as the third domain of life—and an extremophile. It ...

Researchers identified a new, sticky form of mitochondrial DNA damage that builds up at dramatically higher levels than in ...

James Watson, who co-discovered the double-helix structure of DNA in 1953, has died at age 97. Born in Chicago in 1928, Watson made the groundbreaking discovery at just 24 years old alongside British ...

The intriguing findings bolster the theory that asteroids seeded the early Earth with life's chemical components - a process ...

We have long struggled to determine how the first living organisms on Earth came together. Now, surprising evidence hints ...