This study identifies 47,350 enhancers active in human neurons during differentiation and links some to genes involved in ...

It both stabilizes a critical protein called RNA Polymerase II — the molecular engine of gene transcription — and reshapes the structure of chromatin, the tightly packed form of DNA ...

This inactivation is through epigenetic mechanisms — modifications to the genome that do not alter the DNA sequence but regulate gene expression ... Sex-chromosome-related genetic differences ...

“Given the fact that the X chromosome is enriched for brain-related genes, it became very important for us to know what roles it might be playing in brain aging,” said Samira Abdulai ...

To turn genes off and on, cells use Structural Maintenance of Chromosomes (SMC) motors that act like switches to connect different parts of DNA," first author Roman Barth explains. "However ...