本研究系统揭示了DNA双链断裂修复后的一个被长期忽视的层面：染色质结构与基因功能的不可逆改变。这种结构性与功能性损伤可稳定地传递给子代细胞，形成一种可遗传的基因表达缺陷，被作者定义为“染色质疲劳（chromatin ...

Researchers at The University of Texas MD Anderson Cancer Center have performed a comprehensive evaluation of five artificial ...

Fluorogenic DNA aptamers produce light only in the correct structural state, enabling programmable molecular logic, ...

Tiny repeated stretches of DNA in your genome may quietly shape how your body works, how your brain develops and how you ...

When people think of DNA, they visualize a string-like double helix structure. In reality, the DNA double helix in cells is supercoiled and constrained into loops. This supercoiling and looping are ...

A change in the DNA sequence of a codon may not change the corresponding amino acid residue in the encoded protein because each residue can be encoded by several codons. This is called the Wobble ...

Researchers identified a new, sticky form of mitochondrial DNA damage that builds up at dramatically higher levels than in ...

Every face carries a story, shaped long before birth by a quiet choreography of genes switching on and off at just the right moment. A new study suggests that part of that story reaches far back into ...

Researchers uncovered an overlooked layer of genetic variation: subtle sequence changes within short tandem repeats. Studying genomic data from over 3,000 people, they found these variations are ...

Millions of people worldwide live with mitochondrial diseases. These are inherited conditions that make it hard for the body’s cells to produce energy. For a long time, patients had few options ...