When DNA breaks inside the cell, it can spell disaster, especially if the damage occurs in areas of the genome that are difficult to repair. Now, scientists Irene Chiolo and Chiara Merigliano at ...

CryoEM structure of the RAD51 D-loop. Credit: eLife (2025). DOI: 10.7554/eLife.107114.1 Researchers have revealed the structural mechanisms of a major DNA repair pathway in human cells.

DNA repair is essential for the maintenance of genomic stability and its failure can lead to human disease. Various DNA repair systems exist, such as base excision repair, nucleotide excision ...

Breakthrough Research and Therapeutic Implications for Huntington’s Disease Mouse models have shown that targeting the DNA mismatch repair protein MSH3 can effectively halt or slow the expansion ...

DNA repair: A look inside the cell's 'repair café' Date: November 21, 2024 Source: Hubrecht Institute Summary: New research sheds light on how cells repair damaged DNA. For the first time, the ...

Chemistry DNA repair has been captured in a step-by-step molecular movie Researchers have worked out how a protein called photolyase repairs DNA using light, and their discoveries could guide the ...

DNA.. Abstract future innovation dna molecule helix spiral laser therapy on white background. Medical science, genetic biotechnology, chemistry biology, gene cell concept vector 3d illustration DNA ...

A novel technology combined with optical tweezer C-trap technology gives researchers new insight into DNA repair mechanisms. Researchers at the University of Pittsburgh (PA, USA) have developed a ...

1 Introduction Deleterious aberrations in DNA repair genes are found in a considerable rate of patients with advanced prostate cancer (PC) (1 – 3). With the advent of target therapy such as ribose ...

This Collection focuses on various DNA repair mechanisms, their biological roles in preventing human disease, and therapeutic strategies for disorders of defective DNA repair.

Researchers have found that people who live beyond 105 years tend to have a unique genetic background that makes their bodies more efficient at repairing DNA, according to a new study.