The head of a woman was discovered on June 12, 1993 in New Scandia Township's Bone Lake. The case remains unsolved. Investigators hope new DNA analysis will lead to answers.

Homologous recombination, already known for its role in repairing DNA double-strand breaks [4], is shown here to be essential specifically at replication forks. This specificity underscores the ...

Summary: Researchers have discovered that the protein USP50 regulates DNA replication by managing which enzymes—nucleases or helicases—cleave or unwind DNA strands during replication. This control is ...

Protein involved in balancing DNA replication and restarting found USP50 protein helps balance nuclease and helicase activity during critical processes Date: October 14, 2024 Source: University of ...

Recent findings reveal that early mouse embryos replicate their DNA in a unique, uniform manner, which changes after the embryo grows beyond four cells. This early-stage replication is slower and more ...

Embryonic stem cells maintain high origin activity and slow forks to coordinate replication with cell cycle progression. EMBO Reports, 2024; DOI: 10.1038/s44319-024-00207-5 ...

In mammalian cells, tens of thousands of DNA replication origins are activated in the S phase to start genomic duplication. Each origin must be ‘fired’ only once to prevent DNA over-replication and ...

Arrested replication forks, when restarted by homologous recombination, result in error-prone DNA syntheses and non-allelic homologous recombination. Fission yeast RTS1 is a model fork barrier used to ...

TU Delft researchers have developed a new method to assemble and image the molecular motor CMG in DNA replication, offering unprecedented resolution and insights into the replication process. This ...