Ensuring that DNA replication occurs at the right stage of the cell cycle is of crucial importance in biology. In bacteria, DNA replication begins with the assembly of a DNA-protein complex called the ...

The discovery of DNA ligase by the Gellert, Lehman, Richardson, and Hurwitz teams in 1967 was a breakthrough in molecular biology. These essential enzymes maintain genome integrity and play a vital ...

Their findings, which were published March 7 in Science, one of world’s leading scientific journals, not only reveal new details about how secondary DNA structures like G4s can impede DNA replication, ...

Protein involved in balancing DNA replication and restarting found USP50 protein helps balance nuclease and helicase activity during critical processes Date: October 14, 2024 Source: University of ...

Recent findings reveal that early mouse embryos replicate their DNA in a unique, uniform manner, which changes after the embryo grows beyond four cells. This early-stage replication is slower and more ...

Replication complexes, or replisomes, are removed from DNA upon completion of DNA synthesis, but the importance of replisome removal, as well as how cells might respond to defects in this process, has ...

When it comes to DNA replication, humans and baker's yeast are more alike than different Date: August 1, 2024 Source: Van Andel Research Institute Summary: Humans and baker's yeast have more in ...

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The initiation of DNA replication starts at the tail end of the previous cell division and continues through the cell cycle phase known as G1. DNA synthesis happens during the S phase.

DNA replication is an essential nuclear process for genome stability maintenance. Physical barriers and difficult-to-replicate regions hinder replication fork progression and threaten the fidelity of ...

A-DNA forms in a shorter, right-handed double helix. The function of this form is to protect DNA. DNA will revert to this type when it's dehydrated. Z-DNA has a left-handed double helix structure.

In this paper, we present a discrete event method to implement the simulation of DNA replication process. This method focuses on analyzing features about DNA replication, finding the transition among ...