is a measure of the amount of strand breaks in the DNA and is used to provide important new information about male fertility.

Males, with their single X chromosome ... This stalled meiotic progression coincided with the activation of a DNA damage checkpoint, triggered by double-strand break formation, leading to defects like ...

This assay measures the presence of free 3′ hydroxyl groups indicative of DNA strand fragmentation ... is an important clinical parameter for men undergoing fertility evaluation.

Each time a cell divides, the two resulting daughter cells must contain exactly the same genetic information, or DNA, as the parent cell. To accomplish this, each strand of existing DNA acts as a ...