We identify drug metabolites from liver microsomes (e.g., mouse, rat, dog, and human) and in vivo studies. Identifying the unstable moieties can help guide the synthetic optimization of lead compounds ...

Drug-induced liver injury (DILI) is common because it can be caused by different pharmacological ... as they discuss the current understanding of the mechanisms that contribute to DILI and how ...

we assay stability in liver microsomes and perform reaction phenotyping against an array of CYP450s. Core personnel provide advice on the use of the supported methods for a wide variety of ...

By Sriparna Roy (Reuters) -Akero Therapeutics shares gained 106% before the bell on Monday, after its lead drug showed it can ...

Next, Shulman and his team want to use their method to test the effects of these and other metabolism-related drugs on liver ...

"Fortunately, we're not aware of similar chlorcyclizine metabolism differences ... by preventing liver damage at a much earlier stage. The antihistamine allergy drugs have been used safely for ...

One such disease, nonalcoholic steatohepatitis (NASH), is characterized by dysregulated metabolism ... relevant reductions in markers of liver fat, inflammation and fibrosis (Fig.

Obesity is a significant global health challenge, linked to an increased risk of conditions like diabetes, heart disease, and fatty liver. Despite its widespread impact, there is currently no ...