The liver is the major site of drug metabolism. Approximately 60 percent of marketed drugs are metabolized by hepatic CYP450s. Human liver microsomes (HLM) are an important in vitro experimental model ...

Drug-induced liver injury (DILI) is common because it can be caused ... understanding of the mechanisms that contribute to DILI and how advances in reactive metabolism trapping have improved detection ...

Scientists at Michigan Medicine have made a significant breakthrough in treating nonalcoholic fatty liver disease (NAFLD), a ...

By Sriparna Roy (Reuters) -Akero Therapeutics shares gained 106% before the bell on Monday, after its lead drug showed it can ...

The NMR and Drug Metabolism Core at Baylor College of Medicine offers tools ... In addition to analyzing biological fluids or tissues, we assay stability in liver microsomes and perform reaction ...

"Fortunately, we're not aware of similar chlorcyclizine metabolism differences ... by preventing liver damage at a much earlier stage. The antihistamine allergy drugs have been used safely for ...

Obesity is a significant global health challenge, linked to an increased risk of conditions like diabetes, heart disease, and fatty liver. Despite its widespread impact, there is currently no ...

Discover how tirzepatide, a diabetes drug, offers hope for congenital generalized lipodystrophy (CGL) treatment, potentially ...

GATC West Virginia played a role in a groundbreaking AI-powered analysis of a new cancer drug in development — an analysis that saved inestimable hours and dollars for the client. \Calif.-based GATC ...