Researchers have developed an advanced model that facilitates the study of drug metabolism during pregnancy by ...

We identify drug metabolites from liver microsomes (e.g., mouse, rat, dog, and human) and in vivo studies. Identifying the unstable moieties can help guide the synthetic optimization of lead compounds ...

"It is a long way from insights in mouse experiments to bringing a drug to the market – but this is obviously the potential ...

Most drug-metabolizing enzymes discussed in this review (e.g., CYP isoenzymes, N-acetyltransferase) are located primarily in the liver and, to a lesser extent, in other organs, such as the small ...

Most drugs are metabolized by CYP3A enzymes, and variations in expression levels of these enzymes are believed to determine whether patients will have a positive or adverse drug response.

Drug-induced liver injury (DILI) is common because it can be caused by different pharmacological ... as they discuss the current understanding of the mechanisms that contribute to DILI and how ...

A study published in Nature Aging has revealed a promising new drug candidate that may help combat metabolic dysfunction-associated steatotic liver disease (MASLD), a chronic liver condition that ...

More than 100 million Americans struggle with obesity and related metabolic disorders, a staggering number with widespread ...

Solute carrier (SLC) family transporters are crucial transmembrane proteins responsible for transporting various molecules, including amino acids, electrolytes, fatty acids, and nucleotides. To date, ...

Ready to save your liver? Transcription factors are paving the way for metabolic dysfunction-associated fatty liver disease ...

Hitting a plateau after a steady run of weight loss has derailed many health and fitness plans. But what if you could flick a ...

Drug-induced liver injury (DILI) is a significant concern in clinical practice, arising from medications, herbs, and dietary supplements.