Cytoplasmic dynein is a vital microtubule-based motor protein that drives retrograde intracellular transport, supporting essential cellular functions ranging from organelle positioning to cell ...

Movement signals life, and nowhere is this truer than inside a living cell. The millions of proteins and molecules within each of our cells bend, travel and conform in a complex but orchestrated ...

Understanding how chromosomes separate during cell division could help scientists understand birth defects such as Down's syndrome, where chromosomes do not separate properly, and how to stop cancer ...

During mitosis in budding yeast, dynein moves the mitotic spindle into the mother-bud neck. We have proposed an offloading model to explain how dynein works. Dynein is targeted to the dynamic plus end ...

CORVALLIS, Ore. (KTVZ) – Oregon State University scientists say they have taken a key step toward better understanding neurodegenerative diseases by using a suite of biophysical techniques to learn ...

The paper A.K. Rai et al., “Molecular adaptations allow dynein to generate large collective forces inside cells,” Cell, 152:172-82, 2013. Inside every cell is a busy transit system, with motor ...

image: This artist's conception -- which will be the cover art for the April 16 issue of the journal Cell-- shows three molecular motors that help move cells and things inside them. The details of how ...

The most lethal feature of any cancer is metastasis, the spread of cancer cells throughout the body. New research reveals the mechanics behind how breast cancer cells may invade healthy tissues. The ...

Maintenance of genome integrity in germ cells is crucial for the success of future generations. In Drosophila, and mammals, transposable element activity in the germline can cause DNA breakage and ...

Dyneins are eukaryotic force-generating ATPases responsible for movement along microtubules, driving the beating of cilia and flagella, and key cytoplasmic processes, such as intracellular transport ...

Scientists have taken a key step toward better understanding neurodegenerative diseases by using a suite of biophysical techniques to learn more about a motor protein whose malfunction is associated ...