Mutations in single genes can increase the lifespans of lower metazoan organisms (worms and flies) and mammals. Many of these mutations affect genes that are involved in endocrine signalling pathways.

Sickle cell disease (SCD) is an autosomal, recessive hemoglobinopathy characterized by hemolytic anemia, intermittent occlusion of small vessels leading to acute and chronic tissue ischemia, and organ ...