The physiological effects of estrogens are mediated by two intracellular transcription factors, the estrogen receptors (ERs), that regulate transcription of target genes through binding to specific ...

The first estrogen receptor was discovered in the late 1950s, a period that Jan-Ǻke Gustafsson refers to as BC (before cloning). Forty years later, he and colleagues were looking for a completely ...

The clinicopathologic importance of a second estrogen receptor (ER), ER-β, in breast cancers has been intensely studied; however, there is still no real consensus regarding the clinical utility of an ...

In a study using a mouse model of aging that mimics breast cancer development in estrogen receptor-positive post-menopausal women, investigators have determined that over-expression, or switching on ...

FLD is a metabolic dysfunction encompassing several liver pathologies, ranging from intracellular triglycerides accumulation to severe lipotoxicity and fibrosing steatohepatitis, all of which are ...

Announcing a new publication for Acta Materia Medica journal. Endocrine therapy that blocks estrogen receptor signaling has been effective for decades as a primary treatment choice for breast cancer ...

BioWorld - Thursday, June 19, 2025 Breaking News: Trump administration impacts continue to roil the life sciences sector See today's BioWorld Science Home » A carborane agonist of estrogen receptor β ...

Adenocarcinoma of the lung unrelated to a smoking habit occurs more frequently in women than men, thus suggesting an association between female hormones and development of these tumors. The aim of ...

Cholesterol clears the brain once metabolized to 24-hydroxycholesterol, but that is not the only way 24HC can be beneficial, according to Silvia Maioli at the Karolinska Institutet in Stockholm. In ...

Proceedings of the National Academy of Sciences of the United States of America, Vol. 117, No. 28 (July 14, 2020), pp. 16346-16355 (10 pages) Agonists to the μ-opioid G protein-coupled receptor (μOR) ...

A study led by researchers at the Fujita Health University School of Medicine, in collaboration with Chiba University's Graduate School of Medicine and Fukuoka University, Japan, revealed that ...