Vepdegestrant is an oral proteolysis-targeting chimera (PROTAC) estrogen receptor (ER) degrader that directly harnesses the ubiquitin–proteasome system. In this phase 3, open-label, randomized ...

Discover how high-speed AFM reveals estrogen receptor binding to DNA, enhancing understanding of gene regulation. Learn more about this breakthrough.

Estrogen receptor alpha (ERα), a key nuclear hormone receptor, plays a central role in mediating estrogen’s effects in the female reproductive system. ERα is predominantly expressed in tissues, such ...

Estrogen has protective factors against heart disease. When estrogen levels lower during menopause, the risk of heart disease increases.

Learn about estrogen-dependent cancers, including types, risk factors, and treatment options that target hormone-driven growth.

Our analysis of the PHLDA1 promoter region revealed the presence of several transcription factor binding sites including one imperfect palindrome, direct repeats of half-EREs, one AP1- and three ...

Selective estrogen receptor modulators (SERMs) are a group of medications classified as hormone therapies. Two common SERMs are Nolvadex (tamoxifen) for the treatment of breast cancer and Evista ...

Activity Detection of Estrogen Receptor α Ligand Binding Domain using Proposed Ensemble Learning Abstract: To know whether specific chemical compounds can interfere with bodily functions that might ...

Immunohistochemistry (IHC) is a newer technique for assessing the estrogen receptor (ER) status of breast cancers, with the potential to overcome many of the shortcomings associated with the ...

The use of vaginal estrogen therapy (VET) increased the risk for breast cancer recurrence by 39% in women with early estrogen receptor–positive breast cancer who were taking aromatase inhibitors ...