An estrogen receptor-alpha/p300 complex activates the BRCA-1 promoter at an AP-1 site that binds Jun/Fos transcription factors: repressive effects of p53 on BRCA-1 transcription.

In breast cancer, amplification of the steroid receptor coactivator gene AIB1 is correlated with estrogen and progesterone receptor positivity. Clin. Cancer Res. 4 , 2925–2929 (1998).

Please use one of the following formats to cite this article in your essay, paper or report: APA. AstraZeneca. (2020, January 30). Targeting the Estrogen Receptor in Breast Cancer.

(Funded by Pfizer and Arvinas Estrogen Receptor; VERITAC-2 ClinicalTrials.gov number, NCT05654623.) Notes. This article was published on May 31, 2025, at NEJM.org.

An estrogen receptor that promotes cancer also causes drug resistance. ScienceDaily . Retrieved June 2, 2025 from www.sciencedaily.com / releases / 2021 / 09 / 210923122418.htm ...

To study the function of this new variant, they stably transduced and overexpressed ERα36 in human embryonic kidney cells (HEK293), which do not express the receptor. 2 They showed that ERα36 lacks ...

New generation estrogen receptor-targeted agents in breast cancer: present situation and future prospectives. Acta Materia Medica. 2024. Vol. 3(1):57-71. DOI: 10.15212/AMM-2024-0006. DOI.

Neoadjuvant Chemotherapy and Immunotherapy for Estrogen Receptor–Positive Human Epidermal Growth Factor 2–Negative Breast Cancer. ... these results will make treatment decisions more complex for ...

HER2 tumor marker tests are used to determine whether breast cancer is HER2 positive or negative. A person is a candidate for ...

Estrogen's role in canine mammary cancer is more complex than previously understood, according to new research. The nuanced findings may help explain why dogs spayed at a young age are more likely ...

Researchers in Japan found that estrogen produced within the brain, called neuroestrogen, suppresses appetite and reduces body weight in mice by enhancing MC4R expression. The study also showed ...