Many new molecular mechanisms of genomics, pharmacogenomics, immunology, and other fields are reflected in pathway figures and need to be curated for various applications, especially in precision ...

When confronted with a tachycardia having a broad QRS complex, it is important to be able to differentiate between a supraventricular and a ventricular tachycardia. Medication given for the treatment ...

Abstract This article study the influences of fermented wheat germ on rats in terms of the blood glucose, insulin level, serum lipid level, cholesterol metabolism, triglyceride metabolism and enzyme ...

The discovery could be used to produce therapies that make humans healthier for longer without compromising quality of life ...

It works by blocking a molecular switch that tells cells when nutrients are abundant. Metformin, meanwhile, is a synthetic descendant of a compound found in French lilac (also known as goat’s rue) and ...

For centuries, humans have searched for ways to extend life. Alchemists never found the philosopher’s stone, but scientists have consistently shown that a longer life can be attained by eating ...

Molecular pathways involved with dietary restriction, metformin or rapamycin. Arrows imply activation; bars denote inhibition. Figure designed by ZS using BioRender.com. Credit: Aging Cell (2025).

But this drug, extracted from obscure soil bacteria, shows us that interfering with a single molecular pathway can be enough to mimic the benefits of eating less.

The accumulation of mitochondrial precursor proteins in the cytosol due to mitochondrial dysfunction compromises cellular proteostasis and is a hallmark of diseases. Why non-imported precursors are ...

In fact, another drug that blocks the function of this molecular pathway, in addition to others, has already been tested in patients with myelodysplastic syndrome to induce cancer cell death “which ...

1 School of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Hangzhou, China 2 School of Basic Medical Sciences, Zhejiang Chinese Medical University, Hangzhou, China 3 Academy of Chinese ...

A collaborative research team led by scientists at Thomas Jefferson University has now identified SIRT6 as a critical safeguard of spinal disc health. In findings (DOI: 10.1038/s41413-025-00422-3) ...