This manuscript provides valuable mechanistic insight into NSCLC progression, both in terms of tumour metastasis and the development of chemoresistance. The authors draw upon a range of techniques and ...

YAP and TAZ are part of a critical molecular pathway that usually helps cells grow and repair. However, in a preclinical model of pulmonary fibrosis, the researchers discovered that these proteins ...

Septerna Inc. has announced its decision to discontinue a healthy volunteer phase I trial of SEP-786, an oral small-molecule agonist of the parathyroid hormone 1 receptor being developed for the ...

These findings set the stage for the current studies, which provide the first molecular pictures of KBTBD4 targeting the CoREST complex through interactions induced by both cancer mutations and a ...

Our findings revealed potency ranges for human liver injury with PFAS and AFFF products alongside human drug substances, derived mechanistic pathway potencies and prioritized substances by molecular ...

What is Pathway to Purdue Agriculture? Pathway to Purdue Agriculture is a partnership between the Purdue University College of Agriculture and Ivy Tech Community College-Lafayette designed to help ...

Last, without a full list of the molecular components needed to build ... The organelles of the secretory pathway have been known for over 100 years, but explaining how they are constructed ...

Molecular Cancer Therapeutics publishes articles on the discovery and preclinical development of novel therapeutic agents for oncology, preclinical studies of approved therapeutics, mechanisms of drug ...

This study aimed to investigate the acetylated protein profile alterations and acetylation-mediated molecular pathway changes in human nonfunctional pituitary neuroendocrine tumors (NF-PitNETs). The ...

“Sneezing reflex is mediated by a peptidergic pathway from nose to brainstem,” Cell ... And given the role of sneezing in pathogen transmission, a better understanding of the molecular underpinnings ...

这项研究中所研究的垂体激素，即卵泡刺激激素（follicle-stimulating hormone, FSH），促进卵巢中卵子的成熟。FSH的缺乏会导致不孕 ...

Knowledge of molecular pathways structure and architecture taken along with the gene expression data can help interrogating the pathway activation levels (PALs) using different bioinformatic ...