Kracov has a long history in the rare disease space. He has worked on issues related to the Orphan Drug Act, which was originally passed in 1983 to incentivize the development of drugs for rare ...

In ovarian cancer, FSH upregulates OCT4 expression via the ERK1/2 signaling pathway, contributing to tumor progression (Liu et al., 2015). Elevated OCT4 promotes ovarian cancer cell proliferation and ...

Great progress has been made over the past two decades in establishing how these molecular actors contribute to blood vessel development in the retina, showing in particular that they are involved in ...

Scientists discovered a novel signaling pathway in liver cells, leading to a treatment for fibrosis. A healthy liver filters all the blood in your body, breaks down toxins and digests fats. It ...

XJCRTSZW promotes mitophagy via the in-vivo PINK1/Parkin signaling pathway Transmission electron microscopy showed many swollen mitochondria in GCs with broken, dissolved, or even disappeared cristae, ...

Discovery of cross-species signaling pathway unlocks mysteries around parasite immunity and development Ticks recognize a cytokine from infected mammalian blood, triggering a defense against Lyme ...

Abstract Dopamine drives neuronal excitability via KCNQ channel phosphorylation for reward behavior Highlights Activation of D1R/PKA/ERK pathway increases phosphorylation of KCNQ2 D1R signaling ...

The researchers employed different methods to demonstrate this finding. Using ovariectomized mice, they used anti-FSH antibody treatment to block FSH and inactivate the C/EBPβ/AEP pathway.

Overall, this work strongly shows increased FSH during menopause binds to FSHR in neurons and activates the C/EBPβ/AEP pathway. This process is vital to “triggering” Alzheimer’s onset. “Our findings ...

"During menopause, the serum concentration of FSH strongly increases, binding to the cognate FSH receptor on neurons and activating the C/EBPβ/AEP pathway. This results in Aβ and Tau pathologies ...

The Wnt pathway plays a wide variety of roles in animal and human development, and the ability to regulate it with light will allow researchers to better study its assorted functions.