A defect in a key cell-signaling pathway has been discovered that researchers say contributes to both overproduction of toxic protein in the brains of Alzheimer’s disease patients as well as ...

Scientists are gaining a new understanding of a key signaling pathway in embryo development, tissue maintenance, and cancer genesis. [Chepko/Getty Images] Researchers at the University of Illinois ...

Notch signaling, a key biological pathway tied to development and cell communication, also plays an important role in the onset of obesity and type 2 diabetes, a discovery that offers new targets ...

An activated microglial cell in the brain of cGAS/STING activated mice. [Gulen et al. Nature 02 August 2023. DOI: 10.1038/s41586-023-06373-1] Low-grade inflammation contributes to age-related ...

Recent studies provide new insights into signaling by mutant KRAS, inhibitors of which have provided modest benefits for patients. Skip to main content The New England Journal of Medicine NEJM ...

TGF-β and HIPPO Signaling Pathways. The TGF-β pathway is essential for regulating cell growth, differentiation, and immune responses.

A key signaling target of PD-1–mediated inhibition is the PI3K–Akt pathway 35,36 . Although PI3K–Akt is also a target of CTLA-4, the mechanisms of inhibition induced by these two checkpoint ...