编辑推荐： 为解决抗糖尿病药物联合用药监测难题，研究人员开发了一种基于高效液相色谱-电喷雾串联质谱 (HPLC-ESI-MS/MS)的检测方法，成功实现K3EDTA人血浆中二甲双胍 (MET)和维格列汀 (VLG)同步定量。

所开发的LC-MS分析方法可直接鉴定混合物中的降解物，避免了传统分离纯化的繁琐流程。 这些发现不仅完善了拉呋替丁的质量控制标准，其研究范式（HPLC-UV结合LC-ESI-MS）更为复杂药物分子的降解研究提供了技术蓝本。

Figure 2 shows the structures of the reactive dyes and artificial food dyes examined in this study, highlighting the respective indicative cleavage groups used for analytical detection by LC-ESI-MS/MS ...

Researchers at the Guangdong Key Laboratory for Veterinary Drug Development and Safety Evaluation have developed a high-performance liquid chromatography tandem mass spectrometry (HPLC-MS/MS) method ...

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Yet, none of these works describe the fragmentation mechanisms involved in forming product ions. 13 Gas-phase dissociative reactions, particularly in-source fragmentation processes, are frequently ...

High-performance liquid chromatography-mass spectrometry (HPLC-MS) combines the separation power of LC with the detection specificity of MS. It has become an indispensable analytical tool in the ...