One day, I decided on a whim to try Guix in a VM on an M1 Mac. It seemed like a good idea at the time, but I'd never used Guix before and it ended up being quite a grind to figure out how to get it ...
If you have Git or Python already installed on your system, and you would prefer to use those versions, you may deselect the dependencies you already have and provide a path to the already-installed ...