In our cohort, 6 of 7 patients with isolated anti-Ku presented typical immune-mediated necrotizing myopathy (IMNM)-like pathological features with predominantly necrotic muscle fibre and CD68 + ...

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Objective To elucidate the common and distinct clinical features of immune-mediated necrotising myopathy (IMNM), also known as necrotising autoimmune myopathy associated with autoantibodies against ...

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这类以近端肌无力、肌肉炎症和肌酶升高为特征的自身免疫性疾病，包含免疫介导坏死性肌病（Immune-mediated Necrotizing Myopathy, IMNM）等多个亚型。 近年来，抗3-羟基-3-甲基戊二酰辅酶A还原酶（anti-HMGCR）抗体阳性IMNM的种族差异性引起学界关注，特别是他汀类药物可能通过分子模拟机制诱发该病。

Clinically meaningful drug-free responses were observed in 3 of 4 refractory patients with immune-mediated necrotizing myopathy (IMNM), which are consistent with published data.