By augmenting macrophage TFEB, the master transcriptional regulator of autophagy–lysosomal biogenesis, we can reverse the autophagy dysfunction of plaques, enhance aggrephagy of p62-enriched ...

X. Liao et al., “Macrophage autophagy plays a protective role in advanced atherosclerosis,” Cell Metabolism, 15:545-53, 2012. Atherosclerotic plaques can prompt heart attacks and strokes when ...

This review discusses the cellular process of autophagy ... Liao, X, Sluimer, JC, Wang, Y, et al. Macrophage autophagy plays a protective role in advanced atherosclerosis. Cell Metab 2012;15:545-553.

1. Understand the use of flow cytometry-based medium throughput screening assays as an essential tool to investigate macrophage phagocytosis. 2. Describe the role of pSTAT3 as a pro-phagocytic pathway ...

Autophagy is the body’s way of cleaning out damaged cells, in order to regenerate newer, healthier cells. It allows your body to remove the dysfunctional cells.

TJS and JB are listed as inventors on a related patent, PCT/AU2020/050908 for measurement of autophagy in humans. “The anti-aging MIRACLE.” “Strengthen your immune system.” “Lose weight ...

Role of PI3K/Akt/mTOR pathway-mediated macrophage autophagy in affecting the phenotype transformation of lung fibroblasts induced by silica dust exposure. August 28, 2023 ...

Cell biologist Yoshinori Ohsumi wins the 2016 Nobel Prize in physiology or medicine for discoveries in autophagy. Wait, what's autophagy? Full Episode. Saturday, Jul 5. Close Menu.

PAQ Therapeutics hopes to break into the emerging field of autophagy, which is essentially the cell's garbage disposal, to complement or compete against the broader protein degradation field. The ...

Edinburgh and London, UK, 14 May 2025 – Resolution Therapeutics (“Resolution” or “Company”), a clinical-stage biopharmaceutical company pioneering regenerative macrophage therapy to treat inflammatory ...