An international research team has determined the first high-resolution structures of the herpes simplex virus origin-binding ...

Objectives Patients with primary Sjögren’s disease (SjD) have an increased risk of B cell lymphoma. The aim of this study was ...

Breakthrough cryo-EM structures expose multiple drug targets in an essential HSV-1 replication protein.An international ...

Scientists have discovered how LINE-1, a “jumping gene” that makes up 17% of the human genome, inserts itself into DNA. Using ...

Reviewers viewed the targeting of TFAM as innovative and the study's conclusions as potentially important (especially the effects on inflammation). However, the lack of evidence for a direct effect of ...

Results from pritelivir Phase 2 study demonstrate a favorable safety profile and a numerically higher lesion healing rate vs. foscarnetPritelivir Phase 2 results supported FDA Breakthrough Therapy ...

Long Interspersed Nuclear Element-1 (LINE-1 or L1) is the only active, self-copying genetic element in the human ...

They observe how the mobile DNA LINE-1 copies its sequence in human cells, revealing the precise mechanism of the ORF2p gene.

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. PTGS facilitates but is not required for the ...

These burrowing animals have a biological mechanism that does the opposite of what it does in humans: it repairs DNA instead ...

A research team at the Seville Biomedical Institute (IBis) has identified a new molecular mechanism that explains the high ...