Objective Metabolic reprogramming plays a critical role in modulating the innate and adaptive immune response, but its role in cutaneous autoimmune diseases, such as cutaneous lupus erythematosus (CLE ...

Even well-known drugs can cause entirely unpredictable effects on metabolism, Swiss researchers have shown. Rapidly mapping ...

Although an important link between intestinal metabolites and immune activity is widely established, the metabolic profile of IgAN is still poorly understood, which severely limits the mechanistic ...

Mubritinib has a well-tolerated profile and selectively targets glioblastoma stem cells while sparing normal ... This work highlights mitochondrial respiration as a critical metabolic dependency and ...

Third Harmonic Bio (THRD) announced results from its Phase 1 single and multiple ascending dose clinical trial of THB335 in healthy volunteers.

The identified metabolites are key to exploring the mechanism of TMJOA. Discussion: In the present study, a metabolic profile was constructed and assessed using a much larger number of human SF ...

THB335 Phase 1 data support advancement into Phase 2 clinical trial in chronic spontaneous urticaria (CSU)Company initiating process to leverage ...

The study was a 10-year follow-up study among adolescents living in eastern Finland. The researchers determined the metabolite profiles of heavy- and light-drinking young adults, and used MRI to ...

To overcome the challenges associated with traditional sampling methods, PHCbi engineered a live cell metabolic analyzer (LiCellMo) with electrochemical In-Line sensors and established a method for ...