This syndrome arises from biallelic mutations in mismatch repair (MMR) genes, which are crucial for correcting DNA replication errors. As a result, individuals with CMMRD often experience multiple ...

While lifestyle and environmental factors contribute to cancer risk, family history remains one of the most crucial yet often ...

First-line treatment with targeted therapies plus chemotherapy offered overall response benefits in BRAF V600E-mutant ...

This paper addresses the important question of quantifying epistasis patterns, which affect the predictability of evolution, by reanalyzing a recently published combinatorial deep mutational scan ...

Incidence of mediastinal lymph node positivity in patients undergoing robotic transthoracic esophagectomy.

Driver mutations are the pathophysiological hallmark of the disease, but the role of mutation clearance after transplantation is unclear. In patients with myelofibrosis, clearance of driver ...

A surge in illnesses prompted at least a dozen Oklahoma schools to close or go virtual on Friday. This comes as the state is ...

In early December 2024, a group of researchers published an article in the journal Science, entitled "A single mutation in bovine influenza H5N1 hemagglutinin switches specificity to human receptors".

Impact of sirtuin genes expression on first-line treatment outcomes in patients (pts) with metastatic colorectal cancer (mCRC) enrolled in CALGB/SWOG 80405 (Alliance). This is an ASCO Meeting Abstract ...

Mismatch repair deficient: Mismatch repair deficiency, according to the National Cancer Institute, describes cells that have mutations in genes that are involved in correcting mistakes made when DNA ...

Old drugs from Bristol Myers Squibb and Pfizer have delivered what the companies and researchers believe could establish them ...