Mutation of the MMR genes cause alterations ... forming a machine that translocates bi-directionally from the mismatch to an 'activation' site. In gram-negative bacteria (Escherichia coli) this ...

However, how the mutation causes the disease remains poorly ... However, the mechanistic connections between mismatch DNA repair and selective neuronal vulnerability in Huntington's disease ...

This system provides a sensitive method for probing the integrity of DNA sequences and a completely new approach to single-base mismatch detection. Here we demonstrate the remarkable sensitivity ...

Liu’s team found that the mismatch repair system was less likely to undo edits. The new and improved prime editing system proved far more effective. The editing efficiency varied between cell types ...

The cause of Huntington's disease was discovered over three decades ago--a "genetic stutter" mutation involves repeats of three letters of the DNA, cytosine-adenine-guanine (CAG), in a gene called ...

(Neurology) Mouse models suggested a subset of mismatch repair genes were key drivers of Huntington's disease. (Cell) Smoking and obesity synergistically worsened disease progression and cognitive ...