and mutations in either of these genes leads to ineffective mismatch repair, failure to induce apoptosis, and cancer. Because mutations in hMSH2 or hMSH6 result in resistance to mutagens and DNA ...

Chimeric oligonucleotides correct point mutations by using the cellular machinery for homologous recombination and mismatch DNA repair. In this case, the correction restored tyrosinase activity ...

This protein machinery—the DNA mismatch repair system—reversed the prime editor’s changes if it noticed the rewriting. By adding in silent mutations near the edits they made to F508del, Liu’s team ...

Despite recent advances in therapy, certain subtypes of colorectal cancer, such as those that are microsatellite instability ...