点击蓝字关注我们【导读】非小细胞肺癌(Non-small cell lung cancer, ...
EGFR 20 外显子插入(EGFR ex20ins)突变是非小细胞肺癌(NSCLC)中除 EGFR 19 外显子缺失(19-Del)和 21 外显子 L858R 点突变(21-L858R)两大常见突变外的 EGFR 第三大突变,占所有 NSCLC ...
在局部非小细胞 肺癌 ( NSCLC )中,肿瘤利用来自葡萄糖中的碳来供给三羧酸循环(TCA循环)的能力预示着癌症转移在临床上表现地很明显前的数月至数年就会扩散到肺脏外部区域。近日,一篇发表在国际杂志 Cancer Discovery 上题为 ...
Sichuan Kelun-Biotech Biopharma has become the first drugmaker to usher a TROP2-targeted antibody-drug conjugate to ...
【导读】 尽管非小细胞肺癌(NSCLC)的治疗手段有所进步,但耐药性仍是重大挑战。铁死亡是一种受调控的细胞死亡形式,在癌症进展和治疗响应中发挥着关键作用。然而,铁死亡在非小细胞肺癌中的调控机制尚未完全明了。
The updated guidelines note that patients with stage IV NSCLC who have EGFR exon 19 deletions or exon 21 L858R substitutions can receive osimertinib plus platinum doublet chemotherapy or amivantamab ...
Sarcopenia influences toxicity and survival in non-small cell lung cancer, and sarcopenia assessment can be factored into ...
喜树碱(CPT)及其衍生物是常用的抗癌药物,能抑制癌细胞增殖、诱导凋亡、调节自噬,然而耐药性限制了它们在 NSCLC 治疗中的效果。自噬是细胞内高度保守的降解系统,就像细胞的 “清道夫”,负责清除不必要的细胞器和受损蛋白质。但在癌细胞中,自噬却可能帮助癌细胞抵抗化疗药物的攻击,成为癌细胞的 “帮凶”。此外,一些研究表明,苯胺类化合物具有抗癌潜力,或许能为肺癌治疗带来新的希望。
(the "Company") announced that the Company's trophoblast cell-surface antigen 2 (TROP2)-directed antibody-drug conjugate (ADC) sacituzumab tirumotecan (sac-TMT, formerly SKB264/MK-2870) was approved ...
The National Cancer Institute (“NCI”), under its Cooperative Research and Development Agreement (“CRADA”) with PDS Biotech, will lead the Phase 1/2 clinical trial evaluating the combination of ...