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本研究针对视网膜退行性病变中多种细胞死亡机制相对贡献不明的科学问题,通过建立氧化应激、低氧、内质网应激和慢性炎症四种小鼠模型,开展比较转录组学分析。研究发现不同应激源可激活独特的分子特征,其中焦亡(pyroptosis)是跨应激类型的共同激活通路 ...
姜黄素衍生物及金属复合物对胶质瘤细胞的细胞毒性、形态变化、增殖抑制及分子机制研究表明,锌复合物(如DAC-Zn和DiMeOC-Zn)对胶质瘤细胞具有显著毒性(p0.0001),镁复合物(如DAC-Mg和DiMeOC-Mg)在抑制细胞增殖方面效果更佳。机制涉及自噬激活(LC3α/β表达 ...
Purpose: Viral infections elicit different forms of host cell death. Indeed, pathways of programmed cell death (PCD) have emerged as central events in the pathogenesis of various viruses. Regulating ...
Article subjects are automatically applied from the ACS Subject Taxonomy and describe the scientific concepts and themes of the article. Selenium nanoparticles (SeNPs) have gained attention as a ...