First-in-class TMBIM6 therapeutics: Overcoming limitations in current oncology therapies through ERAD-II induced paraptosis.. If you have the appropriate software installed, you can download article ...

Use of AlphaFold 2 to predict stabilizing mutations for the R337H variant in the tetramerization domain of TP53. First-in-class TMBIM6 therapeutics: Overcoming limitations in current oncology ...

We report on the design and synthesis of a green-emitting iridium complex–peptide hybrid (IPH) 4, which has an electron-donating hydroxyacetic acid (glycolic acid) moiety between the Ir core and the ...

该研究首次阐明APEX1-P53-ATF6轴在LECs paraptosis中的核心作用，为ARCC早期干预提供了理论依据。 特别值得注意的是，研究发现传统凋亡关键因子P53在paraptosis中通过调控ERS相关基因发挥非经典功能，拓展了对细胞死亡交叉调控的认知。

Paraptosis Paraptosis, first reported by Bredesen’s group in 2000, is characterized by the extensive vacuolization of ER components and mitochondria swelling, while lacking apoptotic features.

Paraptosis is a vital cell death machinery in generating an anti-tumour effect in various cancer subtypes. Many natural and synthetic compounds have been identified to be potential targets for ...

Paraptosis is characterized by the extensive vacuolization of endoplasmic reticulum (ER) and mitochondria, which will cause the release of damage-associated molecular patterns to promote immunogenic ...

2.1.7诱导肿瘤细胞副凋亡副凋亡（paraptosis）是一种新的细胞程序性死亡形式，由 Sperandio等[91]在2000年首次提出，其典型形态学特征是来源于内质网或线粒体扩张的细胞质空泡化。